Pipeline

Pipeline

The ENABLR technology platform provides an off-the-shelf solution ideally suited to boost T-cell-based therapies (approved or in development) for patients with hematological and solid tumours. It provides a temporary and potent supplement to the patient’s impaired immune system.

Program

  • GY 101 ENABLR +CD3xBCMA
  • GY 201 ENABLR +CD3xCD20
  • GY 301 ENABLR +CD3 x DLL3
  • GY 401 ENABLR +CD3xGPC3

Indication

  • >Multiple MyelomaRelapsing/Refractory (RRMM)
  • >CD20 lymphomaRelapsing/Refractory
  • >Small cell lung cancer(SCLC)
  • >Hepatocellular CarcinomaHCC

Development Stage

Discovery
Preclinical
Phase l
Phase lI
2024
2027
2024
2027
2024
2028
2024
2028

Technology

More Information

The ENABLR technology platform provides an off-the-shelf solution ideally suited to boost T-cell based therapies.

1

T cells are collected from an allogenic healthy donor

2

Cells are modified by replacing the wild type T-cell receptor with a blunted receptor without variable domains

3

In combination with a CD3xTAA bispecific antibody, cells areactivatedand eliminate the cancer cells